ARANESP  4 injection of 80 mcg. 0.5 ml.

WHAT ARANESP  AND WHAT IT IS USED FOR ?
Your doctor has prescribed Aranesp / anti- anemic / to treat your anemia. Anemia is a shortage of red blood cells in the blood, some of the symptoms are fatigue , weakness and shortness of breath .
Aranesp has the same effect as the natural hormone erythropoietin. Erythropoietin is produced in the kidneys and stimulates the bone marrow to produce more red blood cells. The active ingredient of Aranesp is darbepoetin alfa, which is derived by gene technology from Chinese hamster oocytes Ann .

If you suffer from chronic renal failure
Aranesp is used to treat anemia associated with chronic renal failure, the kidneys do not produce enough of the natural hormone erythropoietin , which often causes anemia .
Since the body needs some time to start to produce more red blood cells will feel the effect in about four weeks. The regular course of dialysis does not interfere with Aranesp to treat your anemia.

If you are receiving chemotherapy
Aranesp is used for the treatment of symptomatic anemia in adult cancer patients with non-myeloid formations which have been subjected to chemotherapy .
For the moment, Aranesp should not be administered to patients with tumors in infancy conducting adjuvant or neoadjuvant chemotherapy. If you doubt that this applies to you, talk to your doctor.
One of the major side effects of chemotherapy is that it stops the bone marrow to produce the required cells. In the initial stages the impression that it only affected the production of white blood cells. This is because the red blood cells have a longer life and a longer time in the bloodstream. However, at the end of chemotherapy , especially if it was prolonged , the number of red blood cells may decrease and cause anemia.

BEFORE YOU USE ARANESP
Do not use Aranesp :
- If your blood pressure is difficult to control
- If you are allergic to Aranesp , r-HuEPO or any of the other ingredients.
Check with your doctor :
If you suffer or have suffered from :
high blood pressure , which is not treated with the drugs prescribed by the treating physician
- Sickle cell anemia
- Seizures
- Liver disease
- No response to drugs used to treat anemia

USE Aranesp with food and drink
Food and beverages will impact on Aranesp
 
Pregnancy and lactation
Aranesp has not been tested on pregnant women. It is important to tell your doctor if -
- You are pregnant
- Do you think there is a possibility of pregnancy, or
- Planning to become pregnant

Reduce data whether darbepoetin alfa is excreted in breast milk. We have to stop breast-feeding if you use Aranesp .


DRIVE AND USE MACHINES
Aranesp does not affect your ability to drive or operate machinery.

HOW TO USE PRE- PEN NAPALNETATA ARANESP

After blood tests , your doctor has determined that you need Aranesp . Your doctor will tell you how much you should take . Your doctor has determined that you have to inject under the skin , so you can use Aranesp prefilled pen .

If you suffer from chronic renal failure
The pre-filled pen Aranesp is indicated for a single injection once a week, once every two weeks or once a month.
The initial dose of Aranesp  for the correction of your anemia will be 0,75 μg per kilogram of body weight / fortnightly / or 0,45 μg per kilogram of body weight / weekly / . Your doctor will monitor your blood counts regularly to measure how your anemia is influenced by treatment and may adjust your dose once every four weeks.

After correcting the anemic condition, your doctor will continue to monitor your blood counts and your dose may be further changed to long-term stabilization of anemia. If you are receiving Aranesp once every two weeks , your doctor may change the dose which applies to monthly.
Your blood pressure will also be checked regularly , especially in the initial phase of therapy.
In some cases , your doctor may prescribe additional treatment with iron preparations.
Your doctor may decide that it is necessary to change the method of injection. In this case , you will start with the new method of administration of the same dose that you have taken so far and your doctor will monitor your blood counts to make sure that your anemia responds appropriately.

If you are receiving chemotherapy
Aranesp was administered as a single injection, either once per week and once every three weeks subcutaneously.
The initial dose of Aranesp therapy of anemia will be your 6,75 μg per kg of body weight / every three weeks / or 2,25 μg per kilogram of body weight . Your doctor will monitor your blood counts regularly to determine whether they respond to treatment and may adjust your dose .
Your treatment will last for approximately four weeks after the end of chemotherapy.
Your hemoglobin should not exceed 13 g / dl

How to inject ARANESP  ALONE
Do not try to do the injections if you are not trained .
Never inject Aranesp intravenously alone. Pen is intended for subcutaneous administration.

POSSIBLE SIDE EFFECTS
If you get headaches , especially sudden bouts of stabbing migraine like headaches or feel unwell or if you have seizures , you should immediately consult your doctor. These symptoms may be caused by a sharp rise in blood pressure and may need urgent treatment. It is also an increase in blood pressure , or deterioration of a pre-existing hypertension and even without the presence of these symptoms.

If you are receiving hemodialysis , blood clots can form in your shunt / single channel in which a bypass crosses the blood / . More likely is that to happen if you have low blood pressure or problems with fistula .
If you have kidney problems , you may experience pain around the injection site . This occurs more frequently in Aranesp than with r-HuEPO. The pain is usually not interzivna , its duration is brief and occurs primarily at the beginning of therapy.
If you have a tumor , treatment with Aranesp ® may increase the risk of joint pain, fluid retention , blood clots or pain around the injection site .

In rare cases, allergic reactions, including shortness of breath , skin rash, itching. In isolated cases, neutralizing antibodies to Aranesp  or other recombinant erythropoietin have been reported in patients with chronic renal failure with or without pure red blood cells during treatment with Aranesp .